RodZ, a component of the bacterial core morphogenic apparatus

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RodZ, a component of the bacterial core morphogenic apparatus.

The molecular basis of bacterial cell morphogenesis remains largely an open question. Here we discover a morphogenic protein, RodZ, which is widely conserved across the bacterial kingdom. In Caulobacter crescentus, RodZ is essential for viability and is involved in all aspects of this organism's complex morphology. Depletion or over-production of RodZ results in grossly misshapen cells with sta...

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Interaction of the Morphogenic Protein RodZ with the Bacillus subtilis Min System

Vegetative cell division in Bacillus subtilis takes place precisely at the middle of the cell to ensure that two viable daughter cells are formed. The first event in cell division is the positioning of the FtsZ Z-ring at the correct site. This is controlled by the coordinated action of both negative and positive regulators. The existence of positive regulators has been inferred, but none have p...

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RodZ, a new player in bacterial cell morphogenesis

Three different laboratories have now identified a new morphogenetic factor widely conserved in bacteria. The protein, RodZ, is required for assembly of the actin cytoskeleton MreB that controls cell wall synthesis and cell shape. It is not yet understood how bacteria determine their shape. Almost all bacteria are surrounded by a giant cell wall polymer called peptidoglycan that gives shape to ...

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Morphogenic Protein RodZ Interacts with Sporulation Specific SpoIIE in Bacillus subtilis

The first landmark in sporulation of Bacillus subtilis is the formation of an asymmetric septum followed by selective activation of the transcription factor σF in the resulting smaller cell. How the morphological transformations that occur during sporulation are coupled to cell-specific activation of transcription is largely unknown. The membrane protein SpoIIE is a constituent of the asymmetri...

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ژورنال

عنوان ژورنال: Proceedings of the National Academy of Sciences

سال: 2009

ISSN: 0027-8424,1091-6490

DOI: 10.1073/pnas.0810794106